<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Corradi-Dell'Acqua, C.</style></author><author><style face="normal" font="default" size="100%">Tommelleri, L.</style></author><author><style face="normal" font="default" size="100%">Bellani, M</style></author><author><style face="normal" font="default" size="100%">Rambaldelli, G.</style></author><author><style face="normal" font="default" size="100%">Cerini, R.</style></author><author><style face="normal" font="default" size="100%">Pozzi Mucelli, R.</style></author><author><style face="normal" font="default" size="100%">Balestreri, M</style></author><author><style face="normal" font="default" size="100%">Tansella, M.</style></author><author><style face="normal" font="default" size="100%">Brambilla, P.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Thalamic-insular dysconnectivity in Schizophrenia. Evidence from structural equation modeling</style></title><secondary-title><style face="normal" font="default" size="100%">Human Brain Mapping</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">amygdala</style></keyword><keyword><style  face="normal" font="default" size="100%">dorsolateral prefrontal cortex</style></keyword><keyword><style  face="normal" font="default" size="100%">enthorinal cortex</style></keyword><keyword><style  face="normal" font="default" size="100%">SCAS</style></keyword><keyword><style  face="normal" font="default" size="100%">structural equation modelling</style></keyword><keyword><style  face="normal" font="default" size="100%">voxel-based morphometry</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2012</style></year></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://onlinelibrary.wiley.com/doi/10.1002/hbm.21246/full</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">33</style></volume><pages><style face="normal" font="default" size="100%">740–752</style></pages><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Structural and functional studies have shown that schizophrenia is often associated with frontolimbic abnormalities in the prefrontal, and medio-temporal, regions. It is still unclear, however, if such dysfunctional interaction extends as well to relay regions such as the thalamus and the anterior insula. Here, we measured gray matter volumes of five right-hemisphere regions in 68 patients with schizophrenia and 77 matched healthy subjects. The regions were amygdala, thalamus and entorhinal cortex (identified as anomalous by prior studies on the same population), and dorsolateral prefrontal cortex and anterior insula (isolated by voxel-based morphometry analysis). We employed Structural Equation Modeling, and found altered path coefficients connecting the thalamus to the anterior insula, the amygdala to the DLPFC, and the entorhinal cortex to the DLPFC. In particular, patients exhibited a stronger thalamus-insular connection than healthy controls. Instead, controls showed positive entorhinal-DLPFC, and negative amygdalar-DLPFC, connections, both of which were absent in the clinical population. Our data provide evidence that schizophrenia is characterized by an impaired righthemisphere network, in which intrahemispheric communication involving relay structures may play a major role in sustaining the pathophysiology of the disease.&lt;/p&gt;
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